Mitochondrial Function and Metal Content in Carbon Tetrachloride Poisoning

Poisoning due to use of carbon tetrachloride.

The effect of carbon tetrachloride poisoning on subcellular metal distribution in rat liver.

The mechanism by which the ingestion of carbon tetrachloride results in distinct and reproducible histological alterations of the liver has been investigated intensively, both in &JO and in vitro (3-11). The mitochondria of liver cells are particularly vulnerable to this lipid solvent, as shown by their increased permeability (3), decreased coenzyme content (7, 8), and the loss of their ability...

Acute carbon tetrachloride poisoning. Transaminase and biopsy studies.

Hepatic collagenolytic activity in rats after carbon tetrachloride poisoning.

1. Collagenolytic activity towards acid-soluble collagen labelled with [(14)C]-proline was assayed in rat liver with and without carbon tetrachloride poisoning. The products of enzymic digestion were found to be free amino acids and peptides. 2. The hepatic collagenolytic activity increased under conditions of single-dose and subacute carbon tetrachloride poisoning, and correlated with hydroxyp...

A fatal case of poisoning with carbon tetrachloride.

C. McI., a man aged 26 years, a joiner, on August 12. 1953. during the course of a bout of alcoholism. consumed a quantity of carbon tetrachloride in the form of " thawpit." Shortly afterwards he became intensely nauseated, but was unable to vomit for several hours. Thereafter, however, and for the following 48 hours vomiting was intractable. During this time he complained of pain in the chest,...